Figure 7. CaMKIIδ deletion normalizes the expression of Ca²⁺ regulatory proteins and reduces RyR2 phosphorylation at the CaMKII site after 6-week TAC.

LV homogenates were subjected to Western blotting. Quantitative analysis is shown below. Phosphorylation of RyR2 at the CaMKII site (Ser2815) or at the PKA site (Ser2809) was normalized to RyR expression, and the IP₃R2/RyR ratio was also calculated. Data are mean ± SEM of 3–4 determinations. *P < 0.05, **P < 0.01 versus sham; ^#P < 0.05, ^##P < 0.01 versus WT TAC.