Figure 5.

Impact of advancing age on rate of rise (d[Ca²⁺]_i/dt) of electrical field stimulation–evoked [Ca²⁺]_i transients in the absence and presence of ryanodine in superior cervical ganglion cells from 6- (A), 12- (B), and 24- (C) month-old animals. Cells were activated at various applied currents as per Protocol 1 in the absence (black) and presence (gray) of 100 μM ryanodine (see Methods). N = 19–31 cells from eight animals in each age group. *Significantly different from ryanodine treatment, p < .01 by paired t test.