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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Virus Res. 2008 Aug 15;139(2):148–156. doi: 10.1016/j.virusres.2008.07.007

Fig. 4. A-minor interactions between regions 1 and 2 in the PSIV ribosome-binding domain.

Fig. 4

At left is the structure of the PSIV IGR IRES ribosome-binding domain, with two locations of A-minor interactions colored and highlighted. At right are close-ups of these two locations presented in an orientation looking into the minor groove of helix P2.2. Nucleotides from region 2 are colored yellow, and adenosines from L1.2 of region 1 are colored red. In both sets of interactions, the Abases contact the minor groove side of the helix. In the interaction at top left, the A-bases are at an angle to the bases of the helix, but contacts are still to the minor groove. In the interactions at lower right, the A-bases are closer to being co-planar with those in the helical stack.