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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Semin Cell Dev Biol. 2008 Feb 23;19(3):245–251. doi: 10.1016/j.semcdb.2008.02.003

Fig. 4. APC protein-protein interaction domains.

Fig. 4

Grey: dimerization domain; Black: conserved APC domain. Red: armadillo repeat domain that binds Asef, IQGAP and Kap3. The N-terminal 1121 amino acids also contain a binding site for the B56 regulatory subunit of PP2A. Dark green and dark purple: 3 repeats of 15 amino acids (15aa) and 7 repeats of 20 amino acids (20 aa), respectively, which bind β~catenin. Light purple: 3 SAMP domains in between the 20 aa repeats which bind axin. Yellow: microtubule/F-actin/mDia-binding region between amino acids 2219 and 2580. Olive: C-terminal region that binds to the plus-end microtubule binding protein EB1. Pink: C-terminal S/TXV motif binds to PDZ domains of Dlg, PSD-95.