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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Immunol Rev. 2009 Mar;228(1):93–114. doi: 10.1111/j.1600-065X.2008.00757.x

Fig. 1. Itk and TCR signaling complexes.

Fig. 1

Itk functions in TCR signaling via its interactions in the LAT-SLP-76 signaling complex, where it participates in activation of PLC-γ and the downstream generation of DAG and IP3, as well as regulation of the actin cytoskeleton via interactions with Vav. Rlk is also likely to participate in this context.