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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Immunol Rev. 2009 Mar;228(1):93–114. doi: 10.1111/j.1600-065X.2008.00757.x

Fig. 6. Itk and SAP reciprocally regulate development of conventional and innate T cells.

Fig. 6

Model shows the requirements for Itk and SAP for development of lineages selected on the thymic stroma and hematopoietic cells, respectively. CD28 further contributes to the acquisition of innate-type phenotypes on hematopoietically-selected cells.