Fig. 7. CD2TxkTg decreases development of innate lymphocytes in Itk−/− mice, yet increased percentages of ‘memory-phenotype’ lymphocytes are still present in the periphery.
Thymocytes (left) and splenocytes (right) stained for CD4 and CD8. Gated SP populations were then examined for CD44 levels. Although innate T-cell development is rescued in the thymus, there are still increased percentages of activated/memory phenotype T cells in the periphery of Itk−/−CD2TxkTg mice.