Figure 3.

Low magnification (10x) images of porcine arteries 4 weeks after stent implantation. The images represent stent only (A), untreated tissue as a negative control (B), and delivery of PCN1 ribozyme therapeutic agent (C). Panels A and B show well-defined intimal hyperplasia, whereas panel C shows a significantly lesser amount of neointimal growth. Lower panel images correspond to high magnification of the above. No histological evidence of tissue inflammation is seen. Copyright © 1999. Reproduced from Frimerman A, Welch PJ, Jin X, et al 1999. “Chimeric DNA-RNA hammerhead ribozyme to proliferating cell nuclear antigen reduces stent-induced stenosis in a porcine coronary model.” Circulation, 99:697–703.