Table 2.
Genes used in restenosis therapy
| Cellular target | Action | Gene Product(s) |
|---|---|---|
| Intimal Hyperplasia | Antiproliferative (cytotoxic) | Thimidine kinase, Cytosine deaminase, FasL |
| Antiproliferative (cytostatic) | cdc2, cdk2, cdc2, cyclin B, p21, hRAD 50, p27, p16–p27, p53, Nonphorphorylatable Rb, Rb/E2F chimera, E2F decoy, Truncated PKG PCNA, Egr-1, Dominant-negative H-ras, Gax homeobox, GATA homeobox
IFN-β, Heme oxygenase-1, TIMP, PAI-1 |
|
| Arterial Cytoprotection/intimal hyperplasia | Re-endothelialization
Mixed mechanism |
VEGF
eNOS, iNOS |
| Thrombosis | Antithrombotic | Hiridun, TFPI, Prostacyclin synthase, COX1 |