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. Author manuscript; available in PMC: 2009 Apr 27.
Published in final edited form as: Curr Opin Pharmacol. 2007 Nov 5;8(1):8–13. doi: 10.1016/j.coph.2007.09.009

Figure 2.

Figure 2

Figure 2

Tolerance to the downstream inflammatory effects of TLR4 activation. A. Intracellular signaling events downstream of initial TLR4 activation. Both the MyD88 dependent and MyD88 independent pathways are active. B. Signaling events upon subsequent TLR4 activation. Signaling through the MyD88 dependent pathway is inhibited and signaling through the MyD88 independent pathway is enhanced.

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