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Chimeric animals produced from KCNJ11-deficient embryos and wild-type embryonic stem cells. Surrogate mothers support normal development and give birth to live (three-week-old) chimeric offspring. (a) KCNJ11 knockout wild-type chimera animals develop combination of white and dark coat colours. (b) Three-week-old litter mates: chimera animals are larger than non-chimera animals.
