TABLE 3.

Hair cell survival (percent of control) in the zebrafish lateral line after pretreatment with protective drug followed by variable doses of neomycin

Candidate drug	Neomycin dose given after pretreatment
	0	100	200	400
No pretreatment	100 ± 10	37 ± 20	20 ± 10	13 ± 7
Amsacrine	100 ± 15	83 ± 13*	93 ± 10*	77 ± 17*
Carvedilol	100 ± 10	110 ± 17*	90 ± 13*	80 ± 20*
Cepharanthine	100 ± 11	100 ± 27*	87 ± 30*	97 ± 13*
Drofenine	100 ± 13	67 ± 20*	70 ± 13*	60 ± 13*
Hexamethyleneamiloride	100 ± 11	90 ± 30*	80 ± 20*	73 ± 20*
Phenoxybenzamine	100 ± 10	63 ± 7*	67 ± 10*	60 ± 13*
Tacrine	100 ± 12	80 ± 20*	87 ± 13*	67 ± 13*

Zebrafish were pretreated with highest nontoxic dose of protective drug (100 μM cepharanthine, 50 μM drofenine, 50 μM tacrine, 50 μM carvedilol, 50 μM amsacrine, 50 μM hexamethyleneamiloride, and 50 μM phenoxybenzamine)

*p < 0.01 denotes statistically significant difference compared to control, two-way ANOVA