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. Author manuscript; available in PMC: 2009 Apr 28.
Published in final edited form as: Hum Mol Genet. 2007 Jun 22;16(17):2072–2088. doi: 10.1093/hmg/ddm155

Figure 7.

Figure 7

The localization of matrilin-3 and type IX collagen, but not type II collagen, is disrupted in the growth plates of mutant mice. Representative immunohistochemistry at 6 weeks of age. Immunohistochemical analysis using a COMP antibody revealed less interterritorial staining in the ECM between the proliferating columns which was visible from 3 weeks in the growth plates of mice carrying the p.Thr583Met mutation (circled areas). Matrilin-3 follows the localization of mutant COMP in the growth plate and type IX collagen localization appears to be distinctly altered in the middle of the proliferating zone of the mutant growth plates. Type II collagen localization remains unaltered. Scale bar 100 μm. Key: +/+ (wild-type); m/+ (heterozygous for the mutation); m/m (homozygous for the mutation).