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. 2009 Mar 18;136(9):1453–1464. doi: 10.1242/dev.034967

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Fig. 4. — Rescue of the Foxg1^-/- OE phenotype by loss of Gdf11. (A) Cartoon of normal frontonasal structures in mice at P0, shown as a mid-sagittal section. Red square indicates the region photographed for ISH images shown in B-D. G, serous gland; I, right upper incisor; OB, olfactory bulb; OE, olfactory epithelium; T, turbinate bone; NC, nasal cavity. (B) ISH for Ngn1 to show OE neuronal cells in wild-type animals at P0. (C) Olfactory turbinate structures and Ngn1-expressing OE are not observed in Foxg1^-/- animals. (D) Foxg1^-/-;Gdf11^-/- mice show recovery of turbinate structures and OE expressing Ngn1. Note that there is no OB present in either Foxg1^-/- or Foxg1^-/-;Gdf11^-/-; note also that the telencephalon is drastically reduced in Foxg1^-/- mice and is not rescued by loss of Gdf11 (see Results). Scale bar: 500 μm.