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. 2009 Mar 18;136(9):1453–1464. doi: 10.1242/dev.034967

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Fig. 7. — Downregulation of Fst expression in Foxg1^-/- nasal mucosa is rescued by loss of Gdf11. (A) ISH for Fst performed on coronal sections through heads of wild-type and Foxg1^-/- mice at E10.5 and E12.5, and on horizontal sections at E16.5. At E16.5, when Fst is expressed in both the OE and stroma of nasal mucosa in wild types (A, top right panel), Fst expression is undetectable in Foxg1^-/- embryos in rare instances when remnants of nasal mucosa are observed (A, bottom right panel). NE, nasal epithelium; OE, olfactory epithelium; BL, basal lamina; nc, nasal cavity; Str, stroma; fb, forebrain. Scale bars: 100 μm in E10.5 and E12.5; 50 μm in E16.5. (B) Fst expression is restored in the OE and underlying stroma of Foxg1^-/-;Gdf11^+/- and Foxg1^-/-;Gdf11^-/-. Scale bar: 50 μm.