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. 2009 Apr 10;136(9):1519–1528. doi: 10.1242/dev.029090

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Fig. 6. — Embryonic development of taste bud progenitors is normal without Bdnf-dependent gustatory innervation. (A,B) At E14.5, Shh-expressing taste bud progenitors do not differ between Bdnf^+/+ (A) and Bdnf^-/- (B) littermates. (C,D) In transverse sections of E14.5 tongues immunostained with anti-Shh (green) and anti-Gap43 (red), Shh-IR taste progenitors are comparable regardless of genotype, although Gap-43-IR fiber contact occurs in wild types (C), but is absent in Bdnf^-/- mice (D). (E-G) The number (E) and size (F) of taste progenitors in Bdnf^+/+ versus Bdnf^-/- embryos are not affected by loss of Bdnf-supported innervation (G). (H,I) CK8-IR immature taste buds in sections of E18.5 tongues do not differ between (H) wild-type and (I) Bdnf^-/- embryos. Scale bars: 10 μm in C,D,H,I.