Fig. 1.

Vangl2^Lp mutants have gross morphological defects at E18.5: ∼50% of Vangl2^Lp heterozygote adult females are infertile and have a septate vagina. Wild-type (A) and Vangl2^Lp/Lp mutant (B,C) E18.5 mouse female reproductive tract (FRT). The mutant demonstrates a lack of oviduct coiling and a septate vagina (arrows in C). (D) Wild-type adult FRT. (E) About 50% of Vangl2^Lp heterozygote FRTs are greatly enlarged and fluid-filled, indicating a vaginal blockage. ovi, oviduct; ov, ovary; ut, uterine horn; cx, cervix; vg, vagina; bl, bladder. Scale bars: 1 mm in A,B; 0.5 mm in C; 5 mm in D,E.