Fig. 4.
Vangl2Lp mutants have defective cytoskeletal actin polarization and scribble distribution is not restricted to the apical edge of epithelial cells at E18.5. (A-D) Wild-type (A,C) and Vangl2Lp/Lp mutant (B,D) mouse uterine sections were stained with Alexa 647-phalloidin. C,D are higher magnifications from A,B, with the lumen located towards the upper left in D. (E-H) Scrb1-stained (yellow) uterine sections of wild type (E,G), and Vangl2Lp/Lp mutant (F,H) with the lumen located to the right in G,H. Arrows delineate the apical edge (G,H), which displays increased Scrb1 signal in the Vangl2Lp mutant (H). Scale bars: 10 μm in A,B,E,F; 5 μm in G,H.