Fig. 8.
Model showing how the Vangl2Lp mutation functions in neonatal and postnatal female reproductive tissues. (A) Wild-type neonatal mouse uterine epithelium localizes Vangl2 protein in the apical domain and Scrb1 in the basolateral domain. When Vangl2Lp is mutated, Scrb1 is no longer restricted to the basolateral domain. Wild-type epithelium remains columnar (beneath), whereas Vangl2Lp mutant epithelium is no longer columnar. (B) In postnatal uterine epithelium, Vangl2 is still membraneous, but is enriched at the apical domain, whereas Scrb1 is concentrated at discrete puncta near tight junctions. Wild-type postnatal epithelium remains columnar (beneath), whereas in the Vangl2Lp mutant it becomes highly pseudostratified, indicative of a change in the plane of cell division.