Table 1. Cytogenetic aberrations and correlations with clinical or/and pathological features.

Cytogenetic changes	Chromosomes affected	Specific sites	Special sites	Clinical or/and pathologic features
Chromosomal imbalance aberrations: gain	1, 5, 6, 8, 15, 16, 17, 19, 20, 22, X	1q12-q31, 1q21, 1p3, 5p14-pter, 5p15, 6q, 8q24, 15q12-15, 15q25-->q26, 16p, 17p, 17q, 19, 20q, 22q, Xp	5p14-pter	Reduced survival time
			1q, 5p, 6q, 8q	More frequent in large and very large tumors
			5p	Aggressive behavior
			16p, 17p	More frequent in small tumors
Chromosomal imbalance aberrations: loss	1, 2, 3, 4, 6, 8, 9, 10, 11, 13, 16, 18, 19	1q42-qter, 1p36, 2p, 2q, 2p15-pter, 3p21-p23, 4q, 6q, 8q, 8p21-pter, 9p, 10p, 10q, 10q23-qter, 11p, 11q23-qter, 13q12-q13, 13q14-21, 13q32-qter, 16q, 18p11, 19p13	1p36, 8p21-pter	High risk of metastasis
			13q14-21	Shorter survival time
			10q	Aggressive behavior
			19p13	Development of leiomyosarcoma
Chromosomal imbalance aberrations: amplification	1, 5, 8, 12, 13, 17, 19, 20	1q21, 5p14-pter, 8q, 12q13-15, 13q31, 17p11, 19p13, 20q13	17p	More frequent in small tumors
LOH of D3s1295 and D3s1289	3	3p14.2-23	3p14.2-23	No correlation with grade, size, location
				May harbor tumor suppressor gene
Chromosomal imbalance aberrations	8	Trisomy 8	Not clear	Not clear
Total	25 chromosomes	2,218 genes	2,218 genes	DNA copy number gains more frequent in high-grade leiomyosarcomas
				DNA copy number losses more frequent in low-grade leiomyosarcomas

LOH, loss of heterozygosity