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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Eur J Med Chem. 2008 Apr 29;44(2):460–472. doi: 10.1016/j.ejmech.2008.04.007

Scheme 2.

Scheme 2

Reagents and conditions: a) aryl boronic acid, Pd(Ph3P)4, 1M aq. K2CO3, DME, reflux; b) ethylcholoroaximidoacetate, Et3N, CH2Cl2, rt; c) 4-(4-Trifluoromethoxy-phenoxy)-piperidine or piperidine, tBuONa, PdCl2[(oTol)3P]2, toluene, reflux; d) NH2OH.HCl, Et3N, EtOH, reflux; e) CH(OEt)3, BF3.OEt2, reflux or PhCOCl, Py, reflux