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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Eur J Med Chem. 2008 Apr 29;44(2):460–472. doi: 10.1016/j.ejmech.2008.04.007

Scheme 3.

Scheme 3

Reagents and conditions: a) NH4OH, 1,4-Dioxane, 12 h, rt; b) LiOH, H2O-THF; c) i) (COCl)2, DCM, cat. DMF; ii) n-PrNH2, THF; d) NH2NH2. H2O, EtOH, reflux; e) CH3COCl, Et3N, CH2Cl2, rt; f) i) p-TsCl2, Et3N, CH2Cl2, reflux; ii) 40% K2CO3