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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Eur J Med Chem. 2008 Apr 29;44(2):460–472. doi: 10.1016/j.ejmech.2008.04.007

Scheme 4.

Scheme 4

Reagents and conditions: a) morphiline or 1-benzyl piperazine, tBuONa, PdCl2[(oTol)3P]2, toluene, reflux; b) ethyl choloraximido acetate, Et3N, CH2Cl2, rt; c) DIBAL-H, THF, 0 oC; d) CBr4, Ph3P, NaN3, DMF, rt; e) Ph3P, 1,4-dioxane; f) CH3COCl, Et3N, CH2Cl2, rt.