Table 1.
In vitro anti-tuberculosis activity of C-5 modified isoxazoline ester analogs
| Compd | Structure | MIC (μg/mL) | Compd | Structure | MIC (μg/mL) |
|---|---|---|---|---|---|
| 1 |
|
1.56 | 10a |
|
6.25 |
| 6 |
|
0.8 | 10b |
|
12.5 |
| 7 |
|
50 | 10c |
|
0.8 |
| 8a |
|
12.5 | 10d |
|
1.56 |
| 8b |
|
25 | 15a |
|
100 |
| 8c |
|
0.4 | 15b |
|
6.25 |
| 8d |
|
6.25 | 15c |
|
3.125 |
| 8e |
|
0.8 | 15d |
|
3.25 |
| 9a |
|
1.56 | 17a |
|
25 |
| 9b |
|
1.56 | 17b |
|
6.25 |
| 9c |
|
0.8 | 20a |
|
50 |
| 9d |
|
0.8 | 20b |
|
3.125 |
| 9e |
|
0.8 | 28 |
|
>200 |