Fig. (1).

Control exerted by the Grb7/Grb10/Grb14 proteins on cellular and physiological processes. The cartoon represents a selected series of cellular and physiologically relevant processes in which the Grb7 family member proteins exert a positive or negative control by participating in defined signaling pathways. These processes are: cell migration (Grb7), angiogenesis (Grb7), metabolic control (Grb10 and Grb14), development (Grb10), and cell proliferation (Grb10 and Grb14). Encircled plus and minus symbols represent, respectively, activation and inhibition of the indicated processes. See text for additional details.