Table 1.
Candidate Genes within Chromosomal Linkage Regions Involved in Lipoprotein Metabolism
| Ref. | Subjects | Ethnicity | Linkage Site | LOD | Related Phenotype | Candidate Gene(s) |
|---|---|---|---|---|---|---|
| [147] | Obese families | Caucasian | 12q14.1 | 4.06 | HDL-C | SOAT2, APOF, CYP27B1 |
| [224] | Population based study | Caucasian | 5p13.1 | 3.64 | HDL-C | |
| [146] | Population based study | Mexican Americans | 16q23.1-24.2 | 3.73 | HDL-C | LCAT |
| [225] | Familial combined hyperlipidemia | Caucasian | 3p14 | 3.00 | HDL-C | ACOX2 |
| [148] | Population based study | Caucasian | 15q21 | 4.77 | HDL-C | LIPC |
| [226] | Low HDL-C families | Caucasian | 8q23 | 4.70 | HDL-C | |
| [147] | Obese families | Caucasian | 1q43 11q23.2 15q25.1 19q13.32 |
2.50 3.22 3.11 3.59 |
LDL-C |
ABCB10, GGPS1 ACAT1, APOA1, APOC3 CYP11A LRP3, APOE,LIPE,APOC1 |
| [227] | Type 2 diabetes families | Caucasian | 3p25 2p23 19p13 |
2.47 2.17 2.23 |
LDL-C |
PPARG APOB, LPIN1, ABCG5, ABCG8 LDLR |
| [149] | Healthy children | African Americans | 1p33-35 | 3.60 | LDL-C | PCSK9, LDLRAP1, CYP4A11 |
| [147] | Obese families | Caucasian | 2p14 11p13 11q24.1 |
1.75 | TG |
FABP1 ABCC8, LRP4 ACAT1, APOA1, APOC3, ACAD8 |
| [228] | Hypertriglyceridemic families | Caucasian | 15q21-q24 | 2.56 | TG | LIPC |
| [151] | Obese families | Caucasian | 7q36 | 2.98 | TG | INSIG1, ABCF2, FABP5L3 |
| [150] | Type 2 diabetes families | Caucasian | 15q12-q13.1 | 3.88 | TG | LIPC |
| [229] | Population based study | Caucasian | 7q32.3-qter | 2.50 | TG/HDL-C ratio | ABCF2 |
| [145] | Type 2 diabetes families | Pima Indians | 19p13 | 3.00 | TC | INSR, C3 |
SOAT2 sterol O-acyltransferase 2; APOF apolipoprotein F; CYP27B1 cytochrome P450, subfamily XXVIIB, polypeptide 1; LCAT lecithin: cholesterol acyltransferase; PLAGL1 pleomorphic adenoma gene-like 1; ACOX2 acyl-CoA oxidase 2, LIPC lipase, hepatic; ABCB10 ATP-binding cassette, subfamily B, member 10; GGPS1 geranylgeranyl diphosphate synthase 1; ACAT1 acetyl-CoA acetyltransferase 1; APOA1 apolipoprotein A-I; APOC3 apolipoprotein C-III; CYP11A cytochrome P450, subfamily XIA, polypeptide 1; LRP3 low density lipoprotein receptor-related protein 3; APOE apolipoprotein E; LIPE lipase, hormone-sensitive; APOC1 apolipoprotein C-I; PPARG peroxisome proliferator-activated receptor-gamma; APOB apolipoprotein B; ABCG5 ATP-binding cassette, subfamily G, member 5; ABCG8 ATP-binding cassette, subfamily G, member 8; LDLR low density lipoprotein receptor; PCSK9 proprotein convertase, subtilisin/kexin-type, 9; LDLRAP1 low density lipoprotein receptor adaptor protein 1; CYP4A11 cytochrome P450, subfamily IVA, polypeptide 11; FABP1 fatty acid-binding protein 1; ABCC8 ATP-binding cassette, subfamily C, member 8; LRP4 low density lipoprotein receptor-related protein 4; ACAD8 acyl-CoA dehydrogenase family, member 8; INSIG1 insulin-induced GENE 1; ABCF2 ATP-binding cassette sub-family F member 2; FABP5L3 fatty acid binding protein 5-LIKE 3; INSR insulin receptor; C3 complement component 3.