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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Semin Radiat Oncol. 2008 Oct;18(4):249–256. doi: 10.1016/j.semradonc.2008.04.007

Table 1.

Hypofractionation Trials: Schedules and Equivalent Total Doses in 2-Gy Fractions

Fractionation (tot.dose/fx size/#fx) Total Dose Equivalent if Given in 2-Gy Fractions (NTD2) No. of PTS Institution References
Alpha/Beta = 1.5 (tumor) Alpha/Beta = 3 (late complications)
50 Gy/3.13 Gy/16 fx 66 Gy 61.3 Gy 705 Christie Hosp, Manchester Livsey et al24
69 Gy/3 Gy/23 fx 88.7 Gy 82.8 Gy 52 Gunma, Japan Akimoto et al25
66 GyE/3.3 GyE/20 fx (carbon ions) 90.5 Gy 83.1 Gy 201 NIRS, Chiba, Japan Tsuji et al26
52.5 Gy/2.625 Gy/20 fx 61.9 Gy 59.1 Gy 300 Edenburgh Higgins et al27
56 Gy/3.5 Gy/16 80 Gy 72.8 Gy 36 Jette, Belgium Soete et al28
60 Gy/3 Gy/20 fx 77.2 Gy 72 Gy 92 Princess Margaret Martin et al29
70 Gy/2.5 Gy/28 fx 80 Gy 77 Gy 770 Cleveland Clinic Kupelian et al[19] and [20]
64.7 Gy/2.94 Gy/22 fx 82.6 Gy 77 Gy 100 Multi-institutional trial Ritter et al30
58.1 Gy/3.63 Gy/16 fx 85.1 Gy 77 Gy 100
51.6 Gy/4.3 Gy/12 fx 85.5 Gy 75 Gy 58 (accruing)
52.5/2.625 Gy/20 fx 61.9 Gy 59.1 Gy 466 NCI-Canada (phase III) Lukka et al31
66 Gy/2 Gy/33 fx 66 Gy 66 Gy 470
55 Gy/2.75 Gy/20 fx 66.8 Gy 63.2 Gy 108 Adelaid (phase III) Yeoh et al32
64 Gy/2 Gy/32 fx 64 Gy 64 Gy 109
70.2 Gy/2.7 Gy/26 fx 84.2 Gy 80 Gy 150 Fox Chase (phase III) Pollack et al33
76 Gy/2 Gy/38 fx 76 Gy 76 Gy 150
70 Gy/2.5 Gy/28 fx 80 Gy 77 Gy Ongoing (goal of 1,067 pts) RTOG 0415(phase III) www.rtog.org/members/protocols/0415/0415.pdf
73.8 Gy/1.8 Gy/41 fx 69.6 Gy 70.8 Gy
57 Gy/3 Gy/19 fx 73.3 Gy 68.4 Gy Ongoing (goal of 2,100 pts) MRC (phase III) Khoo et al34
60 Gy/3 Gy/20 fx 77.2 Gy 72 Gy