Table 2.

Phase I/II Ultrahypofractionation Trials: Schedules and Equivalent Total Doses in 2-Gy Fractions

Fractionation (tot.does/fx size/#fx)	Total Dose Equivalent in 2Gy Fractions (NTD₂)		No. of PTS	Institution	References

	Alpha/Beta = 1.5 (tumor)	Alpha/Beta = 3 (late effects)
33.5 Gy/6.7 Gy/5 fx	78 Gy	64.9 Gy	40	Virginia Mason	Madsen et al³⁶
36.25 Gy/7.25 Gy/5 fx	90.6 Gy	74.3 Gy	23 (ongoing)	Stanford	Pawlicki et al³⁷
42.7 Gy/6.1 Gy/7 fx	92.7 Gy	77.7 Gy	105	Umea	Widmark (personal communication, 2008)
35 Gy/7 Gy/5 fx	85.1 Gy	70 Gy	30 (ongoing)	University of Toronto	Tang et al³⁸
47.5 Gy/9.5 Gy/5 fx	149 Gy^*	118 Gy	15	UTSW, Dallas	Timmerman (personal communication, 2008)
50 Gy/10 Gy/5 fx	164 Gy	130 Gy	10 (ongoing)
52.5 Gy/10.5 Gy/5 fx	180 Gy	142 Gy	–

NTD doses based on linear-quadratic modeling may overpredict NTDs for large fractions, as in the UTSW trial.