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. 2009 Apr 28;106(19):7921–7926. doi: 10.1073/pnas.0902191106

Fig. 2.

Fig. 2.

Age-related expression profiles of hFIX minigenes with a hemophilia B Leyden mutation in transgenic mice. (A) Age-related hFIX expression profiles of -416(-20A)FIXm1 in transgenic mice. Serum hFIX concentrations (vertical axis) are plotted against age (horizontal axis). Animals are identified as previously defined by the format [(F or P for founder or progeny, respectively)(identification number)(progeny generation)/(sex)] (1). For founder animals, no progeny generation number is given. Vertical thick green lines represent the relative puberty period. Age 0 represents the birth time point. (B) Age-related hFIX expression profiles of -802(-20A)FIXm1 in transgenic mice. All definitions are as described in A.