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. 2009 Apr 28;106(19):7921–7926. doi: 10.1073/pnas.0902191106

Fig. 5.

Fig. 5.

Molecular mechanisms underlying the puberty-onset amelioration of hemophilia B Leyden in relation to the ASE/AIE-mediated regulatory mechanism. Vertical and horizontal axes are for relative gene expression levels and age, respectively. Relative positions along the age axis for birth, weaning, and puberty are shown with vertical thin orange, green, and a fat light green lines, respectively. A thin gray dotted line represents hFIX expression from the perinatal stage through 1 month of age. Open gray arrows indicate directions of up or down changes in hFIX expression in the presence (+) or absence (−) of ASE and/or AIE. Four age-related patterns of hFIX expression generated by the ASE/AIE-mediated genetic regulation are shown by solid gray lines depicted with specific combinations of ASE and AIE shown with + or − on the right. Age-related patterns of hFIX expression from minigenes -802(-20A)FIXm1 and -416(-20A)FIXm1 carrying a representative Leyden mutation (T-20A) are shown by red and blue curved lines, respectively.