Figure 4.

The relationship between non-synonymous (dN) substitution rate at the contact residues of the ABS and allelic variation of DRB lineages when a) including and b) excluding non-human orthologous lineages (designated with 'W' workshop numbers). Allelic variation was estimated as the number of identified alleles relative to the number of animals sampled. Data were derived from the appropriate GLM model that included species-specific and lineage-specific effects and also the number of animals sampled (see text for details). Back-transformed data are shown; lines are regression lines.