Table 1.
Effects of Competing Drugs on the Binding of [64Cu]Cu-PTSM to HSA
| %Free 64Cu-PTSM (corrected) ± SD (n ≥ 3) in the presence of competing drug | |||||||
|---|---|---|---|---|---|---|---|
| Mole Ratio (Drug:HSA) | Warfarin* | Ibuprofen** | Benzylpenicillin* | Cephmandole | Furosemide* | Phenylbutazone* | |
| 0 | 4.0 ± 0.1 | 4.0 ± 0.1 | 4.0 ± 0.1 | 4.0 ± 0.1 | 4.0 ± 0.1 | 4.0 ± 0.4 | |
| 0.5 | 4.6 ± 0.1 | 3.4 ± 0.1 | 3.8 ± 0.1 | 3.5 ± 0.1 | -- | -- | |
| 1 | 5.8 ± 0.7 | 3.4 ± 0.3 | 3.5 ± 0.1 | 3.2 ± 0.2 | 8.4 ± 0.2 | 7.1 ± 0.1 | |
| 2 | 7.7 ± 0.8 | 3.2 ± 0.5 | 3.3 ± 0.2 | 3.5 ± 0.1 | -- | -- | |
| 4 | 14.8 ± 0.3 | 4.8 ± 0.2 | 3.4 ± 0.1 | 4.2 ± 0.2 | -- | -- | |
| 8 | 20.1 ± 1.5 | 10.1 ± 0.6 | 3.3 ± 0.1 | -- | 32.9 ± 1.1 | 28.7 ± 0.8 | |
*
Binds IIA Site
**
Binds IIIA Site