Table 2.

μCT

	WT	PAPP-A KO	p
2 mo
BV/TV	0.093 ± 0.0072	0.062 ± 0.0063	0.009
Conn.D	73.4 ± 10.49	52.5 ± 10.38	0.063
Tb.N	4.27 ± 0.193	3.46 ± 0.240	0.018
Tb.Th	0.042 ± 0.0013	0.039 ± 0.0010	0.120
Tb.Sp	0.238 ± 0.0098	0.304 ± 0.0198	0.006
6 mo
BV/TV	0.112 ± 0.0112	0.0601 ± 0.0075	<0.0001
Conn.D	43.1 ± 9.28	25.2 ± 5.44	0.100
Tb.N	3.63 ± 0.127	4.00 ± 0.234	0.215
Tb.Th	0.055 ± 0.0017	0.040 ± 0.0010	<0.0001
Tb.Sp	0.283 ± 0.0106	0.261 ± 0.0186	0.363

The tibia was assessed by μCT for the following: BV/TV, relative bone volume; Conn.D, connectivity density, normed by TV (1/mm³); Tb.N, trabecular number (1/mm); Tb, Th, trabecular thickness (mm); Tb.Sp, trabecular separation = marrow thickness (mm).

n = 7−9 mice per group, mean ± SE.