Table 3.

Mechanical Strength Testing

	WT	PAPP-A KO	p
2 mo
E	2606 ± 131	3041 ± 184	0.072
Stress	77.1 ± 2.91	72.3 ± 4.82	0.397
4 mo
E	4169 ± 237	3947 ± 212	0.518
Stress	106.7 ± 3.43	88.6 ± 4.38	0.005
6 mo
E	5085 ± 257	5066 ± 508	0.975
Stress	123.3 ± 4.13	110.5 ± 4.26	0.047

See Materials and Methods section for calculations.

n = 7−10 mice per group, mean ± SE in Mega-Pascals.

E, Young's modulus (measure of stiffness, resistance to deformation); stress: ultimate load stress (measure of strength of the material, resistance to fracture).