Table 5.
Histomorphometry: Trabecular Bone
| WT | PAPP-A KO | p | |
| 2 mo | |||
| BV/TV | 0.049 ± 0.0049 | 0.025 ± 0.0046 | 0.008 |
| Tb.N | 1.95 ± 0.151 | 1.20 ± 0151 | 0.007 |
| Tb.Th | 0.025 ± 0.0094 | 0.022 ± 0.0082 | 0.033 |
| Tb.Sp | 0.556 ± 0.0059 | 1.003 ± 0.0068 | 0.0005 |
| MS/BS | 12.09 ± 2.038 | 9.50 ± 2.534 | 0.450 |
| MAR | 1.151 ± 0.1080 | 0.985 ± 0.0914 | 0.156 |
| BFR/BS | 176 ± 38 | 95 ± 18 | 0.156 |
| BFR/BV | 1,425 ± 302 | 902 ± 160 | 0.246 |
| N.OB | 178 ± 11 | 98 ± 7 | 0.0001 |
| N.OC | 12 ± 2 | 5 ± 1 | 0.0008 |
| N.OB/B.Pm | 40.3 ± 2.94 | 27.0 ± 1.30 | 0.003 |
| N.OC/B.Pm | 2.9 ± 0.64 | 1.3 ± 0.33 | 0.023 |
| 6 mo | |||
| BV/TV | 0.047 ± 0.0051 | 0.026 ± 0.0039 | 0.008 |
| Tb.N | 1.50 ± 0.148 | 1.19 ± 0.155 | 0.184 |
| Tb.Th | 0.029 ± 0.011 | 0.022 ± 0.0097 | 0.0003 |
| Tb.Sp | 0.658 ± 0.0070 | 1.007 ± 0.0026 | 0.133 |
| MS/BS | 12.41 ± 1.601 | 12.56 ± 2.563 | 0.959 |
| MAR | 0.604 ± 0.0491 | 0.511 ± 0.0728 | 0.287 |
| BFR/BS | 28.8 ± 5.07 | 21.0 ± 2.47 | 0.209 |
| BFR/BV | 215 ± 47.1 | 183 ± 16.5 | 0.546 |
| N.OB | 152 ± 15 | 61 ± 14 | 0.002 |
| N.OC | 6 ± 2 | 4 ± 1 | 0.249 |
| N.OB/B.Pm | 42.0 ± 2.35 | 18.7 ± 4.0 | 0.003 |
| N.OC/B.Pm | 1.8 ± 0.37 | 1.4 ± 0.29 | 0.378 |
Values are mean ± SE, n = 6–9 per group.
The distal femur was assessed by bone histomorphometry (see Materials and Methods section) for the following: BV/TV, relative bone volume; Tb.N, trabecular number (1/mm); Tb.Th, trabecular thickness (mm); Tb.Sp, trabecular spacing (mm); MS/BS, mineralizing surface/bone surface (%); MAR, mineral apposition rate (μm/d); BFR/BS, bone formation rate/bone surface (μm3/μm2/yr); BFR/BV, bone formation rate/bone volume (%/yr); N.OB, number of osteoblasts; N.OC number of osteoclasts; N.OB/B. Pm, number of osteoblasts/bone perimeter; N.OC/B.Pm, number of osteclasts/bone perimeter.