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. 2008 Nov 17;68(6):805–811. doi: 10.1136/ard.2008.099291

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Least squares mean change from baseline in American College of Rheumatology (ACR) core component scores (modified intent to treat (mITT) population). Least squares mean change from baseline in (A) tender joint count, (B) swollen joint count, (C) Health Assessment Questionnaire Disability Index (HAQ-DI) and (D) patient’s assessment of arthritis pain (100-mm visual analogue scale (VAS)) were all statistically significantly superior for certolizumab pegol 400 mg vs placebo from week 1 following administration of study drug and at all time points throughout the 24-week study period (p⩽0.01).