Table 2.

Hazard ratios for major cardiovascular event defined as hospitalization or death caused by myocardial infarction, stroke, or ruptured aortic aneurysm or all-cause mortality according to serum levels of cholesterol and its subfractions.

	Major cardiovascular event				All-cause mortality
	Men (n = 195)		Women (n = 199)		Men (n = 210)		Women (n = 222)
	HR (95% CI)*	P	HR (95% CI)*	P	HR (95% CI)*	P	HR (95% CI)*	P
Total cholesterol	1.01 (0.96–1.07)	.68	1.00 (0.93–1.07)	.94	0.97 (0.92–1.02)	.29	0.95 (0.90–1.00)	.065
LDL-C	1.02 (0.96–1.09)	.44	1.02 (0.93–1.11)	.72	0.97 (0.92–1.03)	.34	0.99 (0.92–1.06)	.73
Non-HDL-C	1.03 (0.98–1.09)	.25	1.01 (0.95–1.08)	.77	0.99 (0.95–1.04)	.82	0.97 (0.93–1.02)	.20
Total cholesterol/HDL-C ratio	1.19 (1.00–1.40)	.046	1.13 (0.89–1.45)	.32	1.10 (0.95–1.29)	.20	1.07 (0.90–1.29)	.44
HDL-C	0.76 (0.61–0.94)	.011	0.93 (0.78–1.10)	.40	0.78 (0.65–0.94)	.009	0.93 (0.82–1.07)	.32
HDL-C adjusted†	0.71 (0.55–0.90)	.006	1.01 (0.83–1.23)	.94	0.76 (0.62–0.94)	.011	0.93 (0.80–1.07)	.31

*Hazard ratios and 95% confidence intervals for every unit increase of the total cholesterol/HDL-C ratio and for every 10 mg/dL increase of the other independent variables.

^†Adjusted for smoking, non-HDL-C, triglycerides, diabetes, hypertension, previous stroke, and previous myocardial infarction.