TABLE 7.

Features Associated With the 3 Major LD Phenotypes in JDM

	Generalized LD	Partial LD	Focal LA
JDM features   associated with LD	Joint contractures, calcinosis,   muscle atrophy, chronic   continuous illness course,   malar/facial erythema,   erythroderma, p155   autoantibody	Joint contractures, calcinosis,   muscle atrophy, chronic   continuous illness course,   malar/facial erythema,   erythroderma	Joint contractures, calcinosis,   muscle atrophy, chronic   continuous illness course,   malar/facial erythema,   panniculitis, dysphonia
Fat loss distribution	Face, all extremities,   abdomen/trunk, buccal fat   loss, SQ fat loss on MRI   of thighs with relative   sparing of medial thigh,   SQ fat loss and intraabdominal   fat gain on abdominal MRI	Face, upper > lower extremities,   buccal fat loss, SQ fat loss   on MRI of thighs with relative   sparing of medial thigh	Isolated area on extremity   or buttock at site of   calcinosis
LD clinical features	Steatosis/NASH, ovarian   enlargement, acanthosis   nigricans, hypertrichosis,   low leptin level	Hepatomegaly/steatosis/NASH,   ovarian enlargement,   fat redistribution
LD metabolic features	Hypertriglyceridemia,   insulin resistance >   diabetes, elevated   testosterone	Hypertriglyceridemia, insulin   resistance > diabetes	Hypertriglyceridemia

Abbreviations: SQ = subcutaneous.