Table 4.
Effects of ASI on LVSP, LVEDP and wall stress
| Group | Dose (mg/kg/day) | LVSP (mmHg) | LVEDP (mmHg) | Wall stress (g/cm2) |
| Sham | - | 111.8 ± 12.1 | -0.7 ± 5.8 | 47.7 ± 17.6 |
| Model | - | 88.5 ± 14.0+++ | 13.9 ± 5.4+++ | 125.9 ± 28.0+++ |
| ASI | 0.1 | 101.4 ± 18.5* (0.0367) | 10.6 ± 3.6 (0.1629) | 120.4 ± 31.9 (0.6563) |
| ASI | 0.3 | 101.6 ± 9.0* (0.0340) | 9.8 ± 5.3 (0.0848) | 108.3 ± 24.5 (0.1613) |
| ASI | 1.0 | 100.2 ± 8.4$$ (0.0571) | 6.2 ± 4.2** (0.0018) | 97.9 ± 29.8* (0.0283) |
| Quinapril | 1.0 | 84.0 ± 15.5 (0.4566) | 3.5 ± 6.3*** | 95.1 ± 31.7* (0.0167) |
Note: Values are mean ± SD in each group (n = 10). +++P < 0.001: statistical significance over the sham group (comparison of group means after ANOVA). *P < 0.05, **P < 0.01, ***P < 0.001: statistical significance over the model group (comparison of group means after ANOVA). $$P < 0.01: statistical significance between ASI (1.0 mg/kg/day) and Quinapril treatments (comparison of group means after ANOVA). Exact P values are available in brackets.