Table 5.
Effects of ASI on myocardial hypertrophy
| Group | Dose (mg/kg/day) | LA wt/TL (mg/mm) | LV wt/TL (mg/mm) | RA wt/TL (mg/mm) | RV wt/TL (mg/mm) | Tibial length (mm) | Body weight (g) |
| Sham | - | 1.3 ± 0.6 | 20.3 ± 3.1 | 1.8 ± 0.6 | 5.5 ± 1.5 | 37.25 ± 1.23 | 290.2 ± 23.2 |
| Model | - | 2.8 ± 0.7+++ | 24.9 ± 2.1+++ | 2.6 ± 0.5+++ | 8.1 ± 1.5+++ | 38.20 ± 1.70 | 280.1 ± 24.3 |
| - | - | (0.1879) | (0.3439) | ||||
| ASI | 0.1 | 2.4 ± 0.4 | 22.7 ± 2.8 | 2.5 ± 0.4 | 7.1 ± 1.0 | 38.96 ± 1.28 | 271.2 ± 18.0 |
| (0.1855) | (0.0862) | (0.6751) | (0.1031) | (0.2723) | (0.4038) | ||
| ASI | 0.3 | 2.5 ± 0.7 | 22.6 ± 4.0 | 2.5 ± 0.5 | 7.1 ± 1.2 | 37.23 ± 1.36 | 287.9 ± 31.6 |
| (0.2280) | (0.0796) | (0.7632) | (0.099) | (0.1811) | (0.4639) | ||
| ASI | 1.0 | 2.1 ± 0.6* | 21.0 ± 2.6** | 2.0 ± 0.7* | 6.1 ± 1.3** | 37.89 ± 1.28 | 294.5 ± 15.7 |
| (0.015) | (0.0031) | (0.0186) | (0.0017) | (0.6827) | (0.1794) | ||
| Quinapril | 1.0 | 2.0 ± 0.8** | 22.0 ± 1.8* | 2.0 ± 0.6* | 7.2 ± 1.8 | 38.13 ± 2.27 | 280.1 ± 25.6 |
| (0.0076) | (0.0255) | (0.0223) | (0.1485) | (0.9434) | (1.0) |
Note: Values are mean ± SD in each group (n = 10). +++P < 0.001: statistical significance over the sham group (comparison of group means after ANOVA). *P < 0.05, **P < 0.01: statistical significance over the model group (comparison of group means after ANOVA). No statistical significance between ASI (1.0 mg/kg/day) and Quinapril treatments (comparison of group means after ANOVA). Exact P values are available in brackets.