Table 4.
Extended MHC haplotypes detected only in Thai patients with secondary DHF.
| Patient disease severity | MHC region | ||||||
|---|---|---|---|---|---|---|---|
| class I | class III (central) | class II | |||||
| HLA-A | HLA-B | TNF | LTA | DRB1* | DQB1* | DPB1* | |
| DHF-2 | 2, 11 | 56, 60 | 1, 4 | 1, 3 | *1502,*1602 | *0501,*0502 | *0402,*0501 |
| DHF-2 | 2, 24 | 38, 48 | 1, 4 | 1, 3 | *0405,*1401 | *0402,*0502 | *0501,*2201 |
| DHF-2 | 1, 2 | 57, 75 | 1, 4 | 1, 3 | *0701,*1202 | *0301, *03032 | *0401,*0901 |
| DHF-3 | 1, 11 | 57, 60 | 1, 4 | 1, 3 | *0701,*1502 | *03032,*0501 | *0901,*1301 |
| DHF-1 | 33, 34 | 57, 75 | 1, 4 | 3, 3 | *0701,*1502 | *03032,*0601 | *0501,*0501 |
| DHF-2 | 2, 24 | 48, 62 | 1, 4 | 3, 3 | *1501,*1405 | *05031,*05031 | *0201,*0501 |
| DHF-2 | 2, 24 | 13, 48 | 1, 4 | 3, 3 | *1101,*1602 | *0301, *0502 | *0501,*0501 |
| DHF-2 | 11, 24 | 48, 75 | 1, 4 | 3, 3 | *1101,*1502 | *0301, *0501 | *0501,*1301 |
| DHF-2 | 3, 24 | 38, 57 | 1, 4 | 3, 3 | *0701,*1502 | *03032,*0502 | *0201,*0402 |
| DHF-3 | 2, 2 | 39, 48 | 1, 4 | 3, 3 | *0405,*0405 | *0302, *0302 | *0402,*0501 |
NOTE. DHF disease severity grades 1-3 are defined according to WHO criteria [2]. SNP-defined TNF and LTA haplotype profiles detected only in patients with secondary DHF, and relatively rare HLA alleles and haplotypes associated with null expression of MHC-encoded proteins [31,33], are given in bold.