. Author manuscript; available in PMC: 2009 Apr 29.

Published in final edited form as: Am J Hypertens. 2008 Feb 21;21(5):533–538. doi: 10.1038/ajh.2007.81

Table 2.

Hazard rate ratios (HRRs) relating CFH variant genotypes to incident CHD and ischemic stroke (ISC), in the overall ARIC cohort and by hypertension statue

		Baseline	Period prevalent
Incident CHD	Overall cohort	normotensives	hypertensives

Genotype^a	HRR (95% CI), P	HRR (95% CI), P	HRR (95% CI), P
YH (white)	1.06 (0.94–1.20), 0.3	0.97 (0.83–1.13), 0.7	1.19 (1.01–1.40), 0.03

HH (white)	1.12 (0.95–1.32), 0.2	1.08 (0.88–1.34), 0.5	1.28 (1.04–1.57), 0.02

YH (African Am)	1.14 (0.90–1.43), 0.3	1.20 (0.76–1.89), 0.4	1.13 (0.88–1.44), 0.3

HH (African Am)	0.89 (0.62–1.27), 0.5	1.31 (0.69–2.46), 0.4	0.81 (0.54–1.20), 0.3

Incident ISC	Overall ARIC	Baseline	Period prevalent
	cohort	normotensives	hypertensives

Genotype^a	HRR (95% CI), P	HRR (95% CI), P	HRR (95% CI), P

YH (white)	1.13 (0.86–1.49), 0.4	1.15 (0.79–1.67), 0.5	1.17 (0.84–1.63),0.3

HH (white)	1.47 (1.05–2.05), 0.02	1.62 (1.03–2.55), 0.04	1.46 (0.98–2.18), 0.06

YH (African Am)	1.15 (0.86–1.53), 0.3	1.03 (0.58–1.83), 0.9	1.17 (0.87–1.59), 0.3

HH (African Am)	0.84 (0.53–1.33), 0.5	1.10 (0.48–2.50), 0.8	0.75 (0.45–1.24), 0.3

All analyses adjusted for age and gender.

ARIC, Atherosclerosis Risk in Communities; CFH, complement factor H; CHD, coronary heart disease; CI, confidence interval.

Referent group for analysis: YY; adjustments for additional covariates did not alter the HRRs and P values presented here (data not shown).