Table 4.
Carotid IMT measures by CFH genotype, in the overall ARIC cohort and by hypertension status
| Overall cohort | Baseline normotensives | Period prevalent hypertensives | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CFH genotype | N | Carotid IMT (mm) | P | N | Carotid IMT (mm) | P | N | Carotid IMT (mm) | P |
| White | |||||||||
| YY | 3,383 | 0.727 (0.003) | Ref | 2,545 | 0.711 (0.003) | Ref | 1,495 | 0.762 (0.005) | Ref |
| YH | 4,144 | 0.734 (0.002) | 0.08 | 3,122 | 0.712 (0.003) | 0.8 | 1,859 | 0.776 (0.004) | 0.03 |
| HH | 1,407 | 0.742 (0.004) | 0.003 | 1,031 | 0.720 (0.005) | 0.1 | 656 | 0.787 (0.007) | 0.003 |
| African American | |||||||||
| YY | 1,175 | 0.735 (0.004) | Ref | 559 | 0.705 (0.005) | Ref | 828 | 0.751 (0.005) | Ref |
| YH | 1,434 | 0.735 (0.004) | 1.0 | 667 | 0.703 (0.005) | 0.8 | 1,030 | 0.753 (0.005) | 0.7 |
| HH | 398 | 0.729 (0.008) | 0.5 | 191 | 0.717 (0.009) | 0.3 | 280 | 0.736 (0.009) | 0.2 |
Values are presented as mean (s.e.m.) and adjusted for age and gender; adjustments for additional covariates did not alter the means and P values presented here (data not shown).
ARIC, Atherosclerosis Risk in Communities; CFH, complement factor H; IMT, intima-media thickness.