Table 1.
Body and liver weights and plasma biochemistry of mice
| Db/? control | db/db | Ob/? control | ob/ob | |
|---|---|---|---|---|
| Weight at cull (g) | 25·0±0·54 | 34·5±0·92* | 25·7±0·46 | 42·1±0·55† |
| Liver (g) | 1·31±0·02 | 2·14±0·14* | 1·41±0·08 | 3·79±0·04† |
| Glucose (mg/dl) | 223±14 | 550±68* | 207±109 | 367±42† |
| Insulin (pg/ml) | 1·2±0·2 | 5·5±0·9* | 0·5±0·1 | >12·8† |
| Liver TAG (μmol/g) | 34·7±3·5 | 728±178* | 36·3±5·3 | 2287±130† |
| Corticosterone (nM) | 7·2±1·4 | 60·3±19·5** | 17·9±4·7 | 77·4±16·0† |
Data are mean±s.e.m., compared by Student's t-test. *P<0·005, **P<0·01 for db/db mice versus Db/? control. †P<0·005 versus ob/ob mice versus Ob/? control. N=10–13/group. NB insulin concentrations in all ob/ob mice exceeded the maximum point of the assay. TAG, triglycerides.