Fig. 1.

LPL-mediated uptake of lipids. Left panel: LPL hydrolyzes lipoprotein TG releasing FFAs that are internalized by cells. Much of this uptake is via cell surface receptors such as CD36. Middle panel: LPL also creates remnant lipoproteins that interact with cell surface lipoprotein receptors. Right panel: Another option for uptake of core lipids is that lipolysis creates small particles that contain both surface and core lipid as well as apoproteins, exclusive of apoB. Inactive LPL (iLPL) on the cell surface might facilitate cellular internalization of these particles. Such a pathway might allow cholesteryl and retinyl ester uptake into “high lipolysis” organs such as the heart.