Figure 3.

Reduced amino acid transport in cells infected with viruses that use hATB⁰ for entry. Uptake of glutamine in HT-1080 cells (A) and alanine in HeLa cells (B) was examined in cells cultured after exposure to replication-competent virus indicated on the x axis. The presence of replication competent virus was demonstrated by marker rescue of HT-1080 and HeLa cells exposed to RD114, MPMV, BaEV, and AM-MLV, but was not detected in either cell type exposed to SNV or nil. (Bar represents mean ± SD of triplicate measurements.) Statistical significance of P ≤ 0.01 (∗) and of P ≤ 0.001 (∗∗) was demonstrated by ANOVA in which each result was compared with the result in nil. This experiment was performed twice with similar results.