Table 2.
Mean expression of genes involved in cardiac energy metabolism in LV of lean, obese, or prenatally nutrient-restricted obese offspring
| Gene |
mRNA Abundance in LV, AU |
P
|
|||
|---|---|---|---|---|---|
| L (n = 8) | O (n = 6) | NRO (n = 11) | L vs. O | O vs. NRO | |
| PGC-1α | 1.00±0.08 | 0.55±0.10 | 0.62±0.10 | <0.05 | NS |
| AMPKα2 | 1.00±0.25 | 0.44±0.10 | 0.56±0.08 | <0.05 | NS |
| VDAC | 1.00±0.19 | 0.59±0.14 | 0.36±0.04 | <0.05 | NS |
| GR | 1.00±0.14 | 1.46±0.52 | 0.52±0.09 | NS | <0.05 |
| GLUT1 | 1.00±0.37 | 1.21±0.49 | 0.13±0.04 | NS | <0.05 |
| GLUT4 | 1.00±0.19 | 0.65±0.25 | 0.35±0.01 | NS | NS |
| IR | 1.00±0.39 | 0.63±0.14 | 0.45±0.08 | NS | NS |
Values are means ± SE. AU, arbitrary units; LV, left ventricle; L, lean; O, obese; NRO, nutrient-restricted obese; NS, not significant.