Effect of α1D-adrenoceptor antagonism in isolated mouse aorta. Isolated aortic rings of WT and AhR−/− mice were incubated with phenyleprhine in the absence and in the presence of increasing concentrations of the selective α1D-adrenoceptor antagonist BMY 7378 (●, control; ○, BMY 3 × 10−9 m; ▼, BMY 1 × 10−8 m; ▽, 3 × 10−8 m). Data are reported as a percentage of the maximum response (mean ± SEM, n = 3).