Table 5.
Estimated haplotype frequencies and p values among patients and controls
| Haplotype
|
Frequency, %
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| SNPs, no. | rs10008257 | rs2433320 | rs2433322 | rs2438146 | Patient | Control | p value | p value* | OR (95% CI) |
| 2 | A | A | 1.7 | 3.1 | 0.05 | NS | 0.53 (0.28–1.01) | ||
| G | A | 79.7 | 83.8 | 0.029 | NS | 0.76 (0.59–0.97) | |||
| G | G | 4.0 | 1.1 | < 0.001 | 0.007 | 3.95 (1.85–8.44) | |||
| A | C | 80.0 | 86.3 | 0.003 | NS | 0.67 (0.51–0.87) | |||
| G | C | 5.8 | 2.1 | < 0.001 | 0.005 | 2.95 (1.68–5.20) | |||
| 3 | A | A | G | 3.9 | 2.1 | 0.031 | NS | 1.92 (1.05–3.50) | |
| G | G | A | 44.5 | 49.1 | 0.035 | NS | 0.81 (0.67–0.99) | ||
| G | G | G | 3.1 | 0.7 | < 0.001 | 0.029 | 4.40 (1.76–11.04) | ||
| G | A | C | 78.6 | 83.6 | 0.010 | NS | 0.68 (0.51–0.91) | ||
| G | G | C | 3.2 | 0.4 | < 0.001 | 0.001 | 8.27 (2.55–26.79) | ||
| 4 | A | A | G | T | 3.7 | 2.2 | 0.05 | NS | 1.80 (0.99–3.29) |
CI = confidence interval; NS = no significance after Bonferroni correction; OR = odds ratio; SNP = single nucleotide polymorphism.
*
p values after Bonferroni correction (× 50).