Figure 2. Effect of injection of muscimol or saline into DMH on HR, T_co, and MAP after microinjection of saline into l/dlPAG (n= 6).

A, mean values for heart rate (HR) and mean arterial pressure (MAP) and mean changes from baseline for core body temperature (T_co) over time (min) after microinjection of vehicle (100 nl, grey triangles) or muscimol (100 pmol/100 nl, black squares) into DMH at t= 5 min followed 5 min later by a microinjection of saline into l/dlPAG. Baseline T_co: saline, 37.6 ± 0.2°C; muscimol, 37.3 ± 0.2°C. B, maximum changes in HR, T_co and MAP after microinjection of vehicle/muscimol into DMH followed by microinjection of saline into l/dlPAG. *Significant difference between response to microinjection of muscimol versus saline into DMH by paired t test, P < 0.05.